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OJVRTM
Online Journal of Veterinary Research©
Volume 11(2):38-44,
2007
Phenyl
phosphorodiamidate
(PPD) adversely affects the electrophysiology of the rumen
epithelium in
Sheep
Abdoun
K1, Martens
H2
1Department
of Physiology, Faculty of Veterinary Medicine,
University of Khartoum, 13314 Shambat,
Sudan 2Institute of
Veterinary Physiology, Faculty of
Veterinary Medicine, Free University of Berlin, Oertzenweg
19b, 14163 Berlin, Germany
ABSTRACT
Abdoun
K, Martens H, Phenyl
phosphorodiamidate (PPD) adversely affects
the
electrophysiology of the rumen epithelium in Sheep, Online Journal of Veterinary Research
11(2):38-44, 2007.
The effect of mucosal application of 1mmol/l
phenyl phosphorodiamidate (PPD) on the
electrophysiology
of isolated rumen epithelium was studied in
vitro using a conventional Ussing
chamber technique. Thirty-six isolated rumen epithelium samples from 5
sheep of
different breeds, age and sex and solely fed on hay were used. Mucosal
application
of phenyl phosphorodiamidate, which has an
application in improving the utilization of dietary urea in ruminants
nutrition, on the mucosal side of ruminal
epithelial tissues
resulted in a significant (p<0.05) reduction of the transepithelial
potential difference (PDt) and epithelial
short
circuit current (Isc), and a significant
(p<0.05)
elevation of the epithelial tissue conductance (Gt). Phenyl phosphorodiamidate
could thus impair the barrier and transport function of the rumen
epithelium.
KEY-WORDS:
Electrophysiology;
Phenyl phosphorodiamidate; Rumen; Sheep
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