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OJVRTM
Online Journal of Veterinary Research©
Volume 11 (1) :
75 -88, 2007
Mathematical
description of dose-dependent pharmacokinetics of phenobarbital
Rukhadze
M1,2*,
Bezarashvili G1, Alexishvili
M1, Fischer N3, Sebiskveradze
M2,
Okujava N2, Kirvalidze
L2
1Department
of Chemistry and 2Laboratory
of Neurobiology,Ivane Javakhishvili
Tbilisi State University, I.Chavchavadze
ave.3,
Tbilisi, Georgia,0128 3HELIOS Hospital
Gotha/Ohrdruf,
Helios street 1, 99867 Gotha, Germany
Rukhadze
M, Bezarashvili G, Alexishvili
M, Fischer N, Sebiskveradze M, Okujava
N, Kirvalidze L, Mathematical description of the
dose-dependent pharmacokinetics of Phenobarbital,
Online Journal of
Veterinary Research 11 (1) :
75 -88, 2007
Pharmacokinetic
plasma phenobarbital concentration curves in the rabbit after different
oral doses were derived mathematically.
Humped ascending
branches appeared in the curves at high doses. Absorption and
elimination kinetics
were determined using mathematical successive substitution with
correlation and
regression analysis versus rate constants of absorption and
elimination, as
well as a kinetic order of elimination. Increased dosing significantly
affected
the pharmacokinetics of phenobarbital. The
findings
suggest a step-wise absorption of phenobarbital
into blood.
Key
words: phenobarbital, dose dependent pharmacokinetics;
step-wise
absorption, successive joining up of reservoirs, successive
substitution method