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OJBTM
Online Journal of Bioinformatics©
Database
and interactome map of genes involved
in oral cancer
1Bioinformatics
centre (BTIS Sub-DIC), Advanced Centre for Treatment Research and
Education in
Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India
ABSTRACT
Gadewal NS,
Zingde SM Database and interactome map of genes involved in
oral
cancer, Online Journal of
Bioinformatics,
8 (1) 41-44, 2007. In the
post genomic era, efforts to understand oral cancer are aimed at
obtaining
genomic and proteomic profiles for cancer management. The database in
this report information and
external links for 242
genes
involved in oral cancer, interactions between them, their role in the
biology
of oral cancer, along with clinical relevance. Each gene gives detailed
information on aliases, function, chromosomal location, mutations
and
SNPs, mRNA expression, protein information, pathways involved and
interacting
proteins, expression of genes in different tissues, and clinical
correlates. For querying the database
a search engine retrieves
the genes by symbol, name, chromosomal location, gains and losses of
chromosomal regions and molecular weight. Interactome maps have been
generated
for the genes that are categorized into important biological processes
and molecular
functions based on Gene-Ontology.
KEYWORDS: Oral cancer, Database,
Interactome map