REVIEWER'S PRECIS
This paper addresses an important issue which is the future development of antiviral agents for encephalitis. The paper describes a 3D Japanese encephalitis viral helicase model using yellow fever template. The  use of the yellow fever as the only  template as a suitable homology model (based on 49% identity) appears to be validated but I would suggest that the authors expand or cite use of this template as being appropriate. Apart from this concern, the work is well written, researched and appropriate methods were used. I recommend that this work be published in its present form.


Details below















































BACK TO MAIN
©1996-2007 All Rights Reserved. Online Journal of Bioinformatics.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.

Online Journal of  Bioinformatics

REFEREE FORM


Please complete and remit to Editorial office, Online Journal of Bioinformatics
Author(s): Vlakakis D and Brancale A   Title: The 3D structure of the japanese...  ID:  8748Q,

The Editorial board must ensure that the OJB publishes only papers which are scientifically sound. To achieve this objective, the referees are requested to assist the Editors by making an assessment of a paper submitted for publication by:

(a)  Writing a report on the reverse side of this form,
(b} Check the boxes shown below under 1. and  2. ( YES or NO) [N.B.A "NO" assessment must be
       supported by specific comment in the report.
(c)  Make a recommendation under 3.

The Editor-in-Chief would appreciate hearing from any referee who feels that he/she will be unable to review a manuscript within two weeks.

1. CRITERIA FOR JUDGEMENT (Mark "Yes" or "No").
 

Is the work scientifically sound? Y

Is the work an original contribution  Y
Are the conclusions justified on the evidence presented? (see Comments below)
Is the work free of major errors in fact, logic or technique? Y
Is the paper clearly and concisely written? (see comments below)
Do you consider that the data provided on the care and use of animals (See Instructions to Contributors) is sufficient to establish that the animals used in the experiments were well looked after, that care was taken to avoid distress, and that there was no unethical use of animals? NA


2  PRESENTATION (Mark "Yes" or "No").
 

Does the title clearly indicate the content of the paper? Y
Does the abstract convey the essence of the article? Y
Are all the tables essential? Y
Are the figures and drawings of good quality? Y
Are the illustrations necessary for an understanding of the text? Y
Is the labelling adequate? Y

3. RECOMMENDATIONS(Mark one with an X)
 

Not suitable for publication in the OJB
Reassess after major changes

Reassess after suggested changes

Accept for publication with minor changes  X
Accept for publication without changes


4. REPORT : (Comments)
 This paper addresses an important issue which is the future development of antiviral agents for encephalitis. The paper describes a 3D Japanese encephalitis viral helicase model using yellow fever template. The  use of the yellow fever as the only  template as a suitable homology model (based on 49% identity) appears to be validated but I would suggest that the authors expand or cite use of this template as being appropriate. Apart from this concern, the work is well written, researched and appropriate methods were used. I recommend that this work be published in its present form

©1996-2007 All Rights Reserved. Online Journal of Bioinformatics.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.

BACK TO MAIN