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OJBTM
Online Journal of Bioinformatics©
8 (2)
: 154-164, 2007
The 3D structure of the Japanese
Encephalitis helicase, using homology
based molecular modelling techniques
Vlachakis
D, Brancale A
Vlachakis
D, Brancale A. The 3D
structure of the Japanese Encephalitis helicase,
using homology based molecular modelling technique, Online
Journal of bioinformatics 8 (2) 154-164, 2007. The helicase
plays a key role in the life cycle of viruses of the Flaviviridae family. Japanese encephalitis virus is a member of
this family and constitutes an important human pathogen (1).
In this work, towards a
structure-based
design of novel anti-japanese encephalitis
agents, a
3D-model of the japanese
encephalitis helicase virus was produced
using
homology modelling techniques and the known 3D-structure of the yellow
fever helicase of the Flaviviridae family as template.
Keywords: Homology
modelling;
Molecular Dynamics; Helicase; Japanese
Encephalitis
Virus; Flaviviridae.