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OJVRTM
Online Journal of Veterinary Research©
Volume
10 (2) : 177 - 201,
2006
Clinical significance of
Helicobacter infection in gastric mucosa
of cats
Akhtardanesh
B1, Mohammadi M2,
Jamshidi S3, Sassani F3, Bokaie S3
1Small
animal internal medicine Department, Veterinary faculty, Shahid
Bahanar University, Kerman 2Biotechnology
Research Center,
Pasteur Institute of Iran. 3Veterinary
faculty, Tehran University
ABSTRACT
Akhtardanesh
B, Mohammadi M, Jamshidi S, Sassani F, Bokaie S,
Clinical
significance of Helicobacter infection in
gastric mucosa of cats, Online J
Vet Res,
10 (2) 177-210, 2006. The presence
of spiral bacteria
in the feline stomach has been documented but the zoonotic potential, clinical
importance and prevalence
of these organisms in cats are still poorly documented. The aims of
this study
were to (1) determine the prevalence of feline gastric helicobacters,
(2) study
any existing association between
Helicobacter infection and occurrence of gastritis, (3) evaluate the efficiency of different diagnostic
tools in
detection of gastric helicobacters and (4)
compare
the prevalence of gastric helicobacter infection in pet vs. stray
cats. Thirty adult stray and 27 pet cats
from
different locations were isolated and their gastric samples underwent
cytology,
rapid urease test, histopathology and
genus/species
specific PCRs. According to 16srRNA PCR
assay,
total prevalence of Helicobacter infection was 100% and 56.7% in
domestic and
stray cats respectively. Cats were frequently colonized by Candidatus
H. heilmannii and H. felis
with no direct association to existing chronic gastritis or gastric
lesions. Infected animals generally demonstrated a local immune
response
characterized by lymphoid follicular hyperplasia. Interestingly, the
rate of
Helicobacter infection especially for Candidatus
H. heilmannii was significantly
higher in pet cats
(81%) in comparison with that of the stray group (43.3%) which may
indicate
that living conditions may play an etiologic role in the prevalence of
infection.
Key words: Chronic gastritis, H.
heilmannii, H. felis, H.
pylori,
cat