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OJBTM
Online Journal of Bioinformatics©
Volume
9 (1): 12-20, 2008
Elucidating the role of CREBBP co-activator in
erythroid differentiation by literature mining and
analysis
Iyer J1*, Raghunath A1, Bhate J1
and Wong.L2
1 Molecular Connections Pvt. Ltd, Kandala
Mansions, #2/2 Kariappa Road (South Cross Road), Basavanagudi, Bangalore – 560004, India and 2National
Institute of Singapore, 3 Science Drive 2, Singapore 117543, Republic of
Singapore
ABSTRACT
Iyer J, Raghunath
A, Bhate J, Wong.L Elucidating the role of
CREBBP co-activator in erythroid differentiation by
literature mining and analysis, Online
Journal of Bioinformatics 9
(1): 12-20, 2008. Differentiation
of pluripotent hematopoietic
stem cells into mature circulating erythrocytes are coordinated by
a set of lineage- and tissue specific transcription factors. The two highly
related nuclear proteins CREB binding protein (CBP or CREBBP) and p300 are
co-activators that possess histone acetyltransferase activity, play a central role in the
integration of transcription signals involving diverse cellular processes and
differentiation pathways such as hematopoiesis,
embryogenesis and so .We have been using literature mining successfully to
unravel various biological processes and provide a concise view of regulation
of the physiological networks. An interaction database NetProTM
was used as a source of all interactions in this study. By further network
analysis, CBP is shown as a molecular integrator of hematopoietic
differentiation. Several transcription factor nodes through which the master
regulatory cofactor CBP binds and modulates the expression or activity of
downstream genes involved in erythrocyte
differentiation have been elucidated.
Key words: CBP, CREBBP, erythrocyte differentiation, transcription factor
network, literature mining
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