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OJVRTM
Online Journal of Veterinary Research©
Volume 11 (3)
:24-31,
2007
Pathogenesis of anemia in
Cocker Spaniels with chronic renal
failure
Notomi
MK1, Kogika MM1, Esaine LL1, Coelho BMP2,
Wirth lVFB2 Simões DMN2, Hagiwara
MK1
1Department
of Clinical Medicine of the School
of Veterinary Medicine and
Animal
Science, University of São Paulo
(FMVZ-USP) and 2Veterinary Teaching Hospital – HOVET-FMVZ-USP, 87,
Orlando Marques
Paiva St., Cidade Universitária, São Paulo, Brazil
ABSTRACT
Notomi
MK, Kogika MM, Esaine LL, Coelho BMP, Wirth lVFB, Simões DMN, Hagiwara
MK, Pathogenesis of anemia in
Cocker Spaniels with
chronic renal failure, Online
J Vet Res, 11 (3) : 24-31, 2007. The pathogenesis of anemia in cocker spaniel dogs with
chronic renal
failure (CRF) was evaluated in 15 dogs with CRF and 15 controls without
CRF. Erythrograms,
serum erythropoietin (EPO)
erythrocyte-bound immunoglobulin or complement using Coombs test
were
evaluated in both groups. No difference in EPO serum concentration was
observed
between the groups with CRF, or between sex and age. A positive Coombs
test was
found in 1 CRF dog. Positive correlation were found between serum
concentrations of creatinine and phosphorus (P<0.001) and negative
correlations between packed cell volume and serum creatinine
(P<0.0001), and
packed cell volume with serum phosphorus (P<0.0001). The development
of anemia
correlated with increased serum concentration of creatinine and
phosphorus. Immunomediated
haemolysis, may also contribute to causing anemia. The presence of
non-regenerative anemia could indicate a relative deficit of EPO in
dogs with
CRF, although absolute values were close to the concentrations observed
in the
healthy dogs.
KEY WORDS: anemia,
chronic renal failure, erythropoietin
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