REFEREE FORM
Title: Comparison of
Schuirmann's Two One-sided tests with nonparametric two one-sided test
for normal dta in clinical pharmacokinetic drug-drug interaction studies
(a) Writing a report on the
reverse
side of this form,
(b} Check the boxes shown below under
1. and 2. ( YES or NO) [N.B.A "NO" assessment must be
supported
by specific comment in the report.
(c) Make a recommendation under
3.
The Editor-in-Chief would appreciate hearing from any referee who feels that he/she will be unable to review a manuscript within two weeks.
1. CRITERIA FOR JUDGEMENT (Mark "Yes"
or
"No").
Is the work scientifically sound?Y
Is the work an original contribution ?Y
Are the conclusions justified on the evidence presented?Y
Is the work free of major errors in fact, logic or technique? Y
Is the paper clearly and concisely written? Y
Do you consider that the data provided on the care and use of animals (See Instructions to Contributors) is sufficient to establish that the animals used in the experiments were well looked after, that care was taken to avoid distress, and that there was no unethical use of ahimals? NA
2 PRESENTATION (Mark "Yes" or
"No").
Does the title clearly indicate the content of the paper? Y
Does the abstract convey the essence of the article? Y
Are all the tables essential? Y
Are the figures and drawings of good quality?Y
Are the illustrations necessary for an understanding of the text?Y
Is the labelling adequate? Y
3. RECOMMENDATIONS(Mark one with an
X)
Not suitable for publication in the OJVR
Reassess after major changes
Accept for publication with minor changes
Accept for publication without changes X
4. REPORT
This is a useful comparison report of
schuirmanns TOST with non-parametric TOST for skewed drug-drug
interaction effects. The results support the findings (Bootstrap-T
method) and would be a useful adjunct in clinical pharmacokinetic
studies (small samples sizes). Abstract
and Introduction: Concise and well referenced. Materials and methods, Results and
discussion: Only comment is to centre tables. Recommend
accept without changes and send draft to authors for perusal .
Thank you for opportunity to review this work